Third note on this blog on the subject, this my friend sent me the pharmacist Pantxo Mariscal.
New data confirm that omeprazole may reduce levels of active metabolite of clopidogrel and reduce antiplatelet effect, the English Agency for Medicines and Medical Devices (Competent Authority) recommends that health professionals:
• In patients treated with clopidogrel is not recommended the concomitant use of omeprazole or esomeprazole, unless deemed absolutely necessary. In the latter case, space is not recommended at the time the administration of both drugs, and it does not prevent the interaction between them.
• These recommendations do not currently apply to other PPIs, but not be completely ruled out the interaction, the available evidence does not support this caution. In any case, it is recommended to individually evaluate the need for treatment IBP in patients treated with clopidogrel and the benefits expected of it in relation to their potential risks.
· We advise against concomitant use of clopidogrel with other inhibitors of CYP2C19 than omeprazole or esomeprazole, such as fluvoxamine, fluoxetine, moclobemide, voriconazole, fluconazole, ticlopidine, ciprofloxacin, cimetidine, carbamazepine, oxcarbazepine and chloramphenicol, but it is considered strictly necessary. Read more
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